Keywords
idiopathic thrombocytopenic purpura
treatment
high-altitude climatotherapy
Full Text
Abstract
Introduction. Further improvement of the basic therapy of idiopathic thrombocytopenic purpura (ITP) is still widely discussed by specialists and is the subject of lively discussions.
Aim: to study the dynamics of hemorrhagic syndrome and platelet count in children with ITP in the process of high-altitude climatotherapy and assess the effectiveness of high-altitude hypoxia exposure on the course of the disease.
Materials and methods. The study included 24 children with chronic ITP aged 5 to 14 years (mean age — 10.25 ± 1.43 years) with disease duration from 4 to 8 years. For treatment children were raised to Tuya-Ashu high-altitude base (mountain pass Tuya- Ashu, 3200 m above sea level). The duration of treatment in highlands was 40 days.
Results. By the end of the treatment, the manifestations of hemorrhagic syndrome decreased significantly, the anemic syn- drome completely stopped, the platelet count increased significantly from minimum of 22.1 × 109/L to maximum of 108.4 × 109/L.
Conclusion. High-altitude climatotherapy received 22 children, 2 children had complete remission and 15 — part remission. In 4 children the improvement of clinical and hematological parameters was temporal, and the absence of effect was regis- tered in 1 child. Remission was achieved in 77% of ill children.
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