Individual approach to postoperative thromboprophylaxis in oncology: 616-005.6:616-006.04

Abstract

Aim: to increase prophylaxis effectiveness of venous thromboembolic complications (VTE) in cancer patients under surgery.

Materials and methods. We analyzed the results of anticoagulant postoperative VTE prophylaxis in 216 patients with high risk of thrombosis due to malignant neoplasms of gastrointestinal tract. In dynamics we compared coagulogram parameters, the results of new global hemostatic assessment test, and ultrasound triplex scan of lower limbs venous system during 1 month.

Results. Most VTE cases were registered in patients without medicamentous prophylaxis (26.9%) after surgery. The lowest VTE frequency was observed in patients with individual anticoagulant dose selection (4.9%) based on the global hemostat- ic assessment test.

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11. Conclusion. We consider that in postoperative period in patients with malignant neoplasms of gastrointestinal tract integrat- ed assessment of coagulation system and correction of anticoagulant prophylaxis regimen based on the dynamics of hemo- stasis parameters are required that allows to reduce VTE frequency.