Full Text
Abstract
Aim: to optimize the usage of blood components in patients with coagulopathy we analyze some hemostasis parameters in donors.
Materials and methods. In 200 donors and 50 healthy volunteers (aged from 20 to 60 years old) we analyzed hemostatic pa- rameters: whole blood clotting time, activated partial thromboplastin time, international normalized ratio, platelet aggregation, antithrombin III (AT-III), Claus fibrinogen content, activity of von Willebrand factor (VWF) and factor VIII. The results obtained presented as M ± m. Statistical differences by Student test were considered as significant for p < 0,05.
Results. All donors had the tendency to hypercoagulation with compensatory activation of anticoagulant system. Depending on the age and number of blood donations, obtained blood components were different in platelet aggregation, AT-III level, fi- brinogen content, activity of VWF and factor VIII.
Conclusion. Transfusion therapy of coagulopathies can be optimized through the use of blood components purposefully pre- pared taking into account the nature of blood clotting disorders in the recipient.
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