Screening test for detection of deep vein thromdosis and pulmonary embolism: 616-005.755:616-005.6

Abstract

Introduction. Every year in most countries deep vein thrombosis (DVT) or pulmonary embolism (PE) develops in 80–120 peo- ple per 100 thousand population so screening of hemostatic parameters and assessment of predisposition to thrombosis is very actual problem. D-dimer is the important laboratory marker of thrombosis and thromboembolism. It is of interest to com- pare common clinical tests with different sensitivities to determine whether they can be used during outpatient screening.

Materials and methods. We examined citrate blood samples of 101 patients (mean age — 41 ± 9.1 years) who were divided into 3 groups: 69 persons passed the outpatient examination; 8 patients were in intensive care unit; 24 patients had confirmed cardiovascular disease. Measurement of D-dimer content in citrate plasma samples was carried out simultaneously by 2 meth- ods: immunoturbodimetry (ITD) and immunochemiluminescence (IСL).

Results. We obtained the results of D-dimer levels that were measured by 2 methods and calculated their relationships. The correlation coefficient in different patient groups was 0.74–0.99 depending on their pathology. This fact shows a high de- gree of compliance of D-dimer results and the possibility of using both methods (ITD and IСL) in screening patients for ex- cluding DVT and PE.

Conclusion. Our researches allow to consider the IСL method for studying D-dimer content by Immulite 2000 XPi analyzer as a screening method for outpatient pre-hospital examination.

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