Full Text
Abstract
Introduction. Under the action of excessive stressors of different nature, hemostasis can respond by forming a state of thrombotic readiness. In order to avoid its development, it is necessary to increase body resistance and hemostasis in particular to stress effects. One of the methods is the usage of the products of velvet antler industry.
Aim: to assess hemostasis in rats at a single suprathreshold physical load of different duration and to determine the adaptive role of preliminary intake of a concentrate containing blood and histolysate from maral reproductive organs.
Materials and methods. Studies psychophysiological on 50 male Wistar rats: 4 experimental groups and a group of intact animals, 10 rats each. Animals of groups 1 and 2 were exposed to 4-hour and 8-hour physical load, respectively. Animals of group 3 received products of velvet antler industry (concentrate) for 30 days and on 31st day were exposed to 8-hour suprathreshold physical load. Animals of group 4 received a concentrate for 30 days and were not exposed to physical stress. Intact rats took water in the same volume as experimental animals and were not exposed to physical activity. Hemostasis was assessed by thromboelastography. Histological examination of lungs was carried out in rats from all groups.
Results. The 4-hour physical load caused partial activation of hemostasis, enhancing the phase onset of blood coagulation. The 8-hour physical load caused the development of thrombotic readiness.
Conclusion. Preliminary intake of velvet antler products reduced the risk of thrombotic readiness development and damage of internal organs in rats after suprathreshold coagulopathy load due to increasing of blood fibrinolytic activity.
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