Full Text
Abstract
Aim: to assess the role of hemorheological disorders in the pathogenesis of thrombotic complications in patients with severe thermal injury.
Materials and methods. A prospective analysis of 55 patients examination (13 women and 43 men) aged 18–88 years with severe thermal injury was performed: 19 patients had an instrumental confirmed episode of deep vein thrombosis (DVT) of the lower extremities, 36 patients formed the comparison group. We investigated blood viscosity and elasticity in the shock period of burn disease (1st and 3rd days after the injury), in the stages of toxemia (10th day) and septicotoxemia (20–30th days of burn disease) on the BioProfiler capillary viscometer (USA). Erythrocyte aggregation indices at rest and in motion were determined on MA-1 ag- gregometer (Myrenne GmbH, Germany).
Results. In patients with DVT we observed a significant decreasing of hematocrit and erythrocytes aggregation. Aggregation indi- ces were significantly lower in patients with thrombosis (14.7 ± 1.2 and 26.4 ± 1.9) compared to patients without thrombosis (17.3 ± 0.8 and 29.5 ± 1.3), as well as blood viscosity parameters at shear rates 2.5 s–1 (3.66 ± 0.28 mPa vs. 5.70 ± 1.14 mPa), 12.6 s–1 (3.54 ± 0.37 mPa vs. 4.40 ± 0.39 mPa) and 62.8 s–1 (3.65 ± 0.26 mPa vs. 4.0 ± 0.25 mPa). The blood elasticity at high shear rate (62.8 s–1) in the group with thrombosis was significantly lower (0.23 ± 0.02 and 0.55 ± 0.14 mPa, respectively).
Conclusion. Hemorheological examination of burned patients with DVT of lower extremities revealed decreasing of blood elastici- ty and erythrocytes aggregation compared with the burned patients without thrombotic complications. The combination of blood viscosimetry, elastometry and aggregometry allows to create a hemorheological profile of burn disease and stratifies burned pa- tients according to the degree of thrombotic complications risk.
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