Тромбоз, гемостаз и реология

Tromboz, Gemostaz I Reologiya
scientific and practical journal

ISSN 2078–1008 (Print); ISSN 2687-1483 (online)
2020, COVID
2020

Heparin inhalation in patients with new coronavirus infection (review): 578.834.1:612.115.35

COVID
Published 2020-06-22
Nadezda A. Vorobyeva
Northern State Medical University, Health Ministry of Russian Federation; 51 Troitsky Ave., Arkhangelsk 163000, Russia; Northern branch of National Medical Research Center for Hematology, Health Ministry of Russian Federation;51 Troitsky Ave., Arkhangelsk 163000, Russia;
ФГБОУ ВО «Северный государственный медицинский университет»Министерства здравоохранения Российской Федерации; Россия, Архангельск 163000, Троицкий проспект, 51;Северный филиал ФГБУ «Национальный медицинский исследовательский центр гематологии» Министерства здравоохранения Российской Федерации; Россия, Архангельск 163000, Троицкий проспект, 51;
https://orcid.org/0000-0001-6613-2485 (unauthenticated)
Eugene V. Roitman
Russian National Research Medical University named after N.I. Pirogov, Health Ministry of Russian Federation; 1 Ostrovityanova Str., Moscow 117997, Russia; Research Center of Neurology; 80 Volokolamskoe Highway, Moscow 125367, Russia
ФГАОУ ВО «Российский национальный исследовательский медицинский университет имени Н.И. Пирогова» Министерства здравоохранения Российской Федерации; Россия, 117997 Москва, ул. Островитянова, 1; ФГБНУ «Научный центр неврологии»; Россия, 125367 Москва, Волоколамское шоссе, 80
https://orcid.org/0000-0002-3015-9317 (unauthenticated)
Elizaveta Yu. Melnichuk
Northern State Medical University, Health Ministry of Russian Federation; 51 Troitsky Ave., Arkhangelsk 163000, Russia;
ФГБОУ ВО «Северный государственный медицинский университет» Министерства здравоохранения Российской Федерации; Россия, Архангельск 163000, Троицкий проспект, 51;
https://orcid.org/0000-0002-7000-5451 (unauthenticated)

Keywords

heparin
inhalation
nebulizer
COVID-19
  Full Text

Abstract

Heparin is considered traditionally as an anticoagulant although it has anti-inflammatory, antiproliferative, hypolipidemic (both direct and by increasing the activity of lipoprotein lipase), anticoagulative, anti-edema effects as well. The anti-inflammatory effect of heparin is in the focus of COVID-19 therapy. Inhaled (nebulized) heparin performs local and systemic effects. This way is pathogenetically justified for the prevention and treatment of microvascular thrombosis in lung tissues. Procedures of heparin inhalation should not significantly increase the risk for medical staff to become infected with SARS-CoV-2 when individual protection is fully observed.

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