Effect of parameters of renal replacement therapy on platelet aggregation activity: 616.61-008.64

Abstract

Aim: to assess the effect of renal replacement therapy (RRT) parameters on platelet aggregation activity in patients with chronic kidney disease (CKD).

Materials and methods. For 35 patients with CKD 25 hemodialysis (HD) procedures and 10 hemodiafiltration (HDF) procedures were performed. We studied the dynamics of platelet aggregation activity before and after extracorporeal procedures.

Results. After the HD procedure, platelet aggregation decreased, and after the HDF procedure it increased, without going outside

the normal range. Parameters of RRT procedures did not have a significant effect on platelet aggregation.

Conclusion. A single RRT procedure not more than 4 hours with all nowadays requirements for dialysis therapy does not adversely affect the functional platelets activity. The HDF procedure leads to an unprincipled increasing of platelet aggregation activity.

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