Genes polymorphism involved in regulation of blood vessels function at woman with threatened preterm delivery: 618.39:575.174.015.3

Abstract

Introduction. Threatened preterm delivery is a great medical and social problem. At present, prevention of miscarriage is very actual question because of demographic crisis in Russia. So for most effective diagnostics and prognosis of this pathology further genetic investigations are needed.

The aim: to study polymorphism of hemostasis-associated genes at women with physiological pregnancy and those with threatened preterm delivery among the population of Ivanovo region.

Materials and methods. We examined 176 pregnant women at 22–36 weeks of gestation among population of Ivanovo region: 73 women with physiological pregnancy and 103 women with threatened preterm delivery. We studied the peculiarities of genes polymorphisms (ADD1 G1378T, AGT T704C, AGT C521T, AGTR1 A1166C, AGTR2 G1675A, CYP11B2 -344 C/T, GNB3 C825T, NOS3 -786 T/C, NOS3 G894T) involved in regulation of vascular function.

Results. Genes polymorphisms adversely affecting the vascular wall are common at women in Ivanovo region; some of polymorphisms significantly are more frequent at women with threatened preterm delivery. Probably this can be responsible for disorders of utero-placental blood flow and development of threatened preterm delivery.

Conclusion. Realization of adverse genetic background might be caused by unfavorable environmental factors, their combination is individual.

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