with venous thromboembolic complications of polytrauma: 616-001:616-005.6-005.755:616-057.7:616-092

Abstract

Introduction. Polytrauma is characterized by a specific severity of clinical manifestations, is accompanied by a significant impairment of vital body functions, the difficulty of diagnosis and treatment, frequent development of various complications, prolonged period of hospitalization and high disability. Thromboembolic complications of polytrauma occur in 40–77% of cases
and characterized by latent clinical course, difficulties in treatment and high mortality.

The aim was to study the effect of gene IL2-330T>G polymorphism on the expression of interleukin-2 (IL-2) at patients with
venous thromboembolic complications (VTE) of polytrauma in Zabaykalskiy Krai.

Materials and methods. The study included 114 patients (71,9% men and 28,1% women) with polytrauma aged from 20 to 40
years. Inclusion criteria: polytrauma with index according ISS scale more than 9. First group — 73 patients with uncomplicated polytrauma, second group — 41 patients with VTE of polytrauma. Control group consisted of 100 practically healthy men
and women aged from 20 to 40 years. DNA samples isolated from the peripheral blood were the material for molecular genetic analysis. Point mutation of IL-2 at position 330 (T>G) was selected for study.

Results. Genotype -330T/T of IL2 gene was registered more frequently at patients with VTE of polytrauma; the presence of
this genotype was accompanied by increased production of IL-2.

Conclusion. Identification of genes and their effects on the expression of encoded molecules assists more overall understanding of pathogenetic mechanisms of complications development.

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