Тромбоз, гемостаз и реология

Tromboz, Gemostaz I Reologiya
scientific and practical journal

ISSN 2078–1008 (Print); ISSN 2687-1483 (online)
2021, Original papers
2021

Thrombin generation assay for hemostasis assessment in trans-latitudinal Arctic voyage: 616.151.5:616.153-98

Original papers
Published 2021-10-04
Nadezda Vorobyeva
Northern State Medical University, Health Ministry of Russian Federation; 51 Troitsky Avenue, Arkhangelsk 163000, Russia; Northern Вranch of National Medical Research Center for Hematology, Health Ministry of Russian Federation; 51 Troitsky Avenue, Arkhangelsk 163000, Russia
ФГБОУ ВО «Северный государственный медицинский университет» Министерства здравоохранения Российской Федерации; Россия, Архангельск 163000, Троицкий проспект, 51; Северный филиал ФГБУ «Национальный медицинский исследовательский центр гематологии» Министерства здравоохранения Российской Федерации; Россия, Архангельск 163000, Троицкий проспект, 51
Alyona Vorobyeva
Northern State Medical University, Health Ministry of Russian Federation; 51 Troitsky Avenue, Arkhangelsk 163000, Russia
ФГБОУ ВО «Северный государственный медицинский университет» Министерства здравоохранения Российской Федерации; Россия, Архангельск 163000, Троицкий проспект, 51
Anastasia Marusii
Northern State Medical University, Health Ministry of Russian Federation; 51 Troitsky Avenue, Arkhangelsk 163000, Russia
ФГБОУ ВО «Северный государственный медицинский университет» Министерства здравоохранения Российской Федерации; Россия, Архангельск 163000, Троицкий проспект, 51

Keywords

thrombin generation assay
hypercoagulation
trans-latitudinal voyage
Arctic
sailors
  Full Text

Abstract

Summary. Background. Data are exist about hemostasis activation in the form of hypercoagulation during rotational work in circumpolar territories. Thrombin generation assay (TGA) is a new perspective method for assessing both hyper- and hypocoagula- tion. Objectives: to analyze the dynamics of TGA parameters in trans-latitudinal Arctic sea voyage. Patients/Methods. A prospective clinical and laboratory study was carried out in 52 expedition members during the trans-latitudinal expedition “TransArktika-2019”. Plasma samples for TGA were taken at the zero point (Arkhangelsk, 64°33’ N, 40°32’ E) prior to the ship’s voyage and at the highest point of the expedition (Heiss Island, Franz Josef Land, 80°34’ N, 57°41’ E) on 18–20 days of the voyage. Thrombin kinetic parame- ters were determined on a Ceveron-alpha analyzer with a TGA-module (Technoclone, Austria). Results. At the highest point of the trans-latitudinal voyage, the lag phase (tLag) and the time to peak thrombin (tPeak) were statistically less than at the initial zero point that pointed to hypercoagulation. The endogenous thrombin potential (AUC) values were significantly higher at the highest point. Conclusions. Location in high latitudes is possibly associated with the formation of hypercoagulation.

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