Тромбоз, гемостаз и реология

Tromboz, Gemostaz I Reologiya
scientific and practical journal

ISSN 2078–1008 (Print); ISSN 2687-1483 (online)
2021, Original papers
2021

Blood clotting parameters in revision knee replacement patients with aseptic instability and periprosthetic infection: 612.115.11:616-06:617.3:616.71-003.85:616.94

Original papers
Published 2021-10-04
Svetlana Shakhmartova
Scientific Research Institute of Traumatology, Orthopedics and Neurosurgery, Razumovsky Saratov State Medical University, Health Ministry of Russian Federation; 148 Chernyshevskogo Str., Saratov 410002, Russia
Научно-исследовательский институт травматологии, ортопедии и нейрохирургии ФГБОУ ВО «Саратовский государственный медицинский университет имени В.И. Разумовского» Министерства здравоохранения Российской Федерации; Россия, 410002 Саратов, ул. имени Н.Г. Чернышевского, 148
Irina Vorobyova
Scientific Research Institute of Traumatology, Orthopedics and Neurosurgery, Razumovsky Saratov State Medical University, Health Ministry of Russian Federation; 148 Chernyshevskogo Str., Saratov 410002, Russia
Научно-исследовательский институт травматологии, ортопедии и нейрохирургии ФГБОУ ВО «Саратовский государственный медицинский университет имени В.И. Разумовского» Министерства здравоохранения Российской Федерации; Россия, 410002 Саратов, ул. имени Н.Г. Чернышевского, 148
Daniil Puchinyan
Scientific Research Institute of Traumatology, Orthopedics and Neurosurgery, Razumovsky Saratov State Medical University, Health Ministry of Russian Federation; 148 Chernyshevskogo Str., Saratov 410002, Russia
Научно-исследовательский институт травматологии, ортопедии и нейрохирургии ФГБОУ ВО «Саратовский государственный медицинский университет имени В.И. Разумовского» Министерства здравоохранения Российской Федерации; Россия, 410002 Саратов, ул. имени Н.Г. Чернышевского, 148

Keywords

thrombin generation assay
adaptation
inflammation
total knee replacement
  Full Text

Abstract

Summary. Background. The assessment of adaptive abilities of blood clotting system using thrombin generation assay (TGA) in revision knee replacement patients is a promising issue for researching. Objectives: to assess pre-surgical condition of blood clotting system using TGA in patients admitted for revision knee replacement due to prosthesis aseptic instability or peripros- thetic infection. Patients/Methods. Patients with progressing inflammatory complications admitted for revision knee replacement were divided into two groups: 28 patients with aseptic inflammation and 24 patients with infectious inflammation. Based on TGA findings these groups were divided into subgroups: patients with adequate reaction and those with expressed hemostasis reactions (total of four groups). Plasma hemostasis was assessed by screening coagulogram tests. Inflammation severity was assessed by C-reactive protein (CRP) and fibrinogen levels. Results. It has been demonstrated that patients of these four groups had different adaptive abilities of their blood clotting systems. The most threatened patents for thrombohemorrhagic compli- cations were found in groups 3 and 4 with their responses of thrombin generation process being paradoxical. The impact of inflammation on hypercoagulable syndrome in patients of group 4 proved correlations between TGA and CRP. Conclusions. Analysis of the data obtained revealed the diversity of adaptive abilities of hemostasis in patients with inflammation compli- cations after total knee replacement.

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