Тромбоз, гемостаз и реология

Tromboz, Gemostaz I Reologiya
scientific and practical journal

ISSN 2078–1008 (Print); ISSN 2687-1483 (online)
2021, Clinical cases
2021

Assessment of the economic potential of assisted reproductive technologies in a child with hereditary thrombophilia: 614.2:612.648:612.115.2

Clinical cases
Published 2021-10-04
Anna Plaksina
Ural State Medical University, Health Ministry of Russian Federation; 3 Repin Str., Ekaterinburg 620219, Russia; European Medical Center «UGMK-Zdorovye» LLC; 113 Sheinkman Str., Ekaterinburg 620144, Russia
ФГБОУ ВО «Уральский государственный медицинский университет» Министерства здравоохранения Российской Федерации; Россия, 620219 Екатеринбург, ул. Репина, 3; ООО «Европейский медицинский центр “УГМК-Здоровье”»; Россия, 620144 Екатеринбург, ул. Шейнкмана, 113; 3ФГБОУ ВО «Уральский государственный экономический университет»; Россия, 620144 Екатеринбург, ул. 8 Марта/Народной Воли, 62/45
Alla Oshkordina
Ural State University of Economics; 62/45 March 8/Narodnaya Volya Str., Ekaterinburg 620144, Russia
ФГБОУ ВО «Уральский государственный экономический университет»; Россия, 620144 Екатеринбург, ул. 8 Марта/Народной Воли, 62/45
Olga Kovtun
Ural State Medical University, Health Ministry of Russian Federation; 3 Repin Str., Ekaterinburg 620219, Russia
ФГБОУ ВО «Уральский государственный медицинский университет» Министерства здравоохранения Российской Федерации; Россия, 620219 Екатеринбург, ул. Репина, 3
Nikolay Kuznetsov
Ural State Medical University, Health Ministry of Russian Federation; 3 Repin Str., Ekaterinburg 620219, Russia; Sverdlovsk Regional Children’s Clinical Hospital; 32 Serafima Deryabina Str., Ekaterinburg 620149, Russia
ФГБОУ ВО «Уральский государственный медицинский университет» Министерства здравоохранения Российской Федерации; Россия, 620219 Екатеринбург, ул. Репина, 3; ГАУЗ Свердловской области «Областная детская клиническая больница»; Россия, 620149 Екатеринбург, ул. Серафимы Дерябиной, 32
Tatiana Abolina
Ural State Medical University, Health Ministry of Russian Federation; 3 Repin Str., Ekaterinburg 620219, Russia; Sverdlovsk Regional Children’s Clinical Hospital; 32 Serafima Deryabina Str., Ekaterinburg 620149, Russia
ФГБОУ ВО «Уральский государственный медицинский университет» Министерства здравоохранения Российской Федерации; Россия, 620219 Екатеринбург, ул. Репина, 3; ГАУЗ Свердловской области «Областная детская клиническая больница»; Россия, 620149 Екатеринбург, ул. Серафимы Дерябиной, 32

Keywords

assisted reproductive technologies
children
hereditary thrombophilia
economic efficiency
  Full Text

Abstract

Summary. Introduction. Assisted reproductive technologies (ART) are performed in infertile couples who have, among other things, thrombogenic risk factors that are inherited by their children and can cause disability in the development of vascular catastrophes. The assessment of ART economic potential should take into account the morbidity, disability and mortality of children conceived using these methods. Objectives: to assess ART economic potential in a child conceived with reproductive methods and who has a disability. Patients/Methods. An observational study was conducted on a child conceived using ART and having hereditary thrombophilia. The assessment of ART economic potential was carried out taking into account the indicator of the gross regional product. Results. The child with hereditary thrombophilia in the genes of plasma (FGB –455 G>A), fibrinolytic (PAI‐1–675 5G>4G) and platelet (ITGA2 807 C > T) units of hemostasis, in folate cycle genes, and severe hyperhomocysteinemia had disseminated arte‐ rial thrombosis of the abdominal aorta, which caused amputation of the foot and lower leg, nephrectomy and the formation of disability. Conclusions. Taking into account the infant mortality rate (4.5%) and disability (2.9%) in the group of children conceived with ART (n = 2206), the region has an 11.8‐fold return on the government’s investment in employment in the production of future specialists. Children born in families with thrombogenic risk factors need early care services.

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