Coagulopathy in severe acute pancreatitis: pathogenesis and potential correction methods: 616.37-002:616.151.511

Abstract

Summury. One of the actual problems in acute pancreatitis treatment is blood coagulation disorders, leading to both throm- boembolic complications and disseminated intravascular coagulation. This article summarizes the current concepts of blood coagulation disorders in acute pancreatitis. Systemic inflammation response leads to complex blood coagulation disorder repre- senting in thrombocyte count and function change, hypercoagulation, and secondary hyperfibrinolysis. Anticoagulation system is not effective in hypercoagulation prevention in these settings. Components of both coagulation and anticoagulation systems are considered as therapeutic targets of blood coagulation disorders treatment in acute pancreatitis.

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