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Abstract
Summary. Background. Chronic traumatic encephalopathy (CTE) is a progressive neurodestructive pathology that leads to imminent disability and death of the patient. The leading pathogenetic mechanism is cerebral vascular endothelial dysfunction. Objectives: to study the effect of a new pyrimidine derivative on endothelial functions and plasma hemostasis under conditions of experimental CTE. Materials/Methods. The study was carried out on 50 male Wistar rats divided into 5 groups of 10 animals. The pathology modeling was carried out by a strictly directed mechanical impact of a load (weighing 150 g from a height of 0.5 m) on rat cranium in the parietal region for 7 days (one impact per day). The test compound and reference drugs (choline alfoscerate and hopantenic acid) were administered orally at a dose of 100 mg/kg also for 7 days 30 minutes after injury. The rate of cerebral blood flow, response degree to administration of endothelium-specific analyzers, and hemostasis parameters were studied. Results. In conditions of experimental CTE the endothelium dysfunction of cerebral vessels was revealed. The use of test compound had a positive effect on endothelial functions, in particular, being beneficial in normalization of the rate of cerebral blood flow, response to administration of endothelium-specific analyzers, hemostasis parameters. Conclusions. Further in-depth study of a new pyridine derivative is relevant in order to create an endothelioprotective agent in the treatment of CTE.хроническая травматическая энцефалопатия
References
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