Health status assessment of the newborns with venous thrombosis: 616-005.6

Abstract

Summary. Introduction. One of the most crucial tasks of modern perinatology is prevention and timely diagnosis of neonatal venous thrombosis. At the same time, the risks of thrombotic complications in the “woman–fetus–newborn” system often remain underestimated. Therefore, we should determine perinatal risk factors for thrombosis to improve the algorithm for managing neonates with venous thrombosis. Aim: to determine perinatal risk factors for the development of venous thrombosis to assess the health status of newborns. Materials and Мethods. A retrospective observational diagnostic randomized study included 22 newborns with venous thrombosis who were on heparin therapy and their mothers (n = 22). Research methods: anamnestic, clinical, laboratory (clinical blood test, hemostasis parameters — Quick prothrombin time test, international normalized ratio, fibrinogen, activated partial thromboplastin time, thrombin time, antithrombin III, D-dimer), instrumental (ultrasound of the abdominal cavity and retroperitoneal space, chest x-ray, neurosonography). Results. Family thrombotic history was aggravated in all children. The severe condition of newborns was due to cerebral ischemia (100.0%), venous thrombosis (100.0%), congenital pneumonia (90.9%), conjugative jaundice (77.3%), intranatal asphyxia (63.7%), prematurity (27.3%) and intrauterine growth retardation (27.3%) due to aggravated pregnancy in mothers. Hemostasis parameters in children reflected a high potential for blood clotting and coagulopathy of consumption, while the levels of fibrinogen, antithrombin III, and D-dimer affected by fluctuations in platelet count were significant diagnostic indicators. Conclusion. Timely established family prothrombotic history, identification of clinical, laboratory and instrumental equivalents of hemostatic disorder can prevent venous thrombosis and thrombohemorrhagic complications in newborns with a burdened gestational period.

For citation: IlyinaA.Ya., MishenkoA.L., MartynovA.A., LevchenkoL.A., ShabliyM.V., AkhalovaE.A., RogovaA.S., SolovievaI.V. Health status assessment of the newborns with venous thrombosis. Tromboz, gemostaz i reologiya. 2023;(3):19–27. (In Russ.).

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