Regulatory tool for improving the quality of donor platelet concentrates: 616.411-003.971

Abstract

Summary. Introduction. The current classification of 11 types of donor platelet concentrates in Russia does not account for the possibility of their combined processing. In 2022, a form was proposed for a blood transfusion station report on platelet procurement, which would characterize the number of therapeutic doses received and the use of processes for preparing these doses. Аim: to compare the information content of the regulated and proposed forms of accounting for the procurement of donor platelet concentrates. Materials and Methods.
Based on the results yielded by the Republican Blood Transfusion Station (Ufa), in 2023, prepared 5,541 therapeutic platelet units were taken into account both in the regulated and in the proposed forms. Results. The recommended form in 22 cells considers 4 indicators. The information content of recording whole blood passed through apheresis devices is unclear. There is no evidence that this indicator affects either the quality of the product or the effectiveness of its therapeutic use. The volume of platelet concentrate is of no practical significance: it is the cells that represent the healing factor, not the milliliters. The proposed form in 14 cells takes into account 14 indicators. The proportions of pooled and apheresis platelet concentrates are approximately equal. This was done in consideration of two factors: a) the flow of whole blood donors, from which buffy coat can be isolated and pooled, and b) an order for platelets of specific ABO and antigen D of the Rh blood group system (RhD) phenotypes. In 46.1% of therapeutic doses of platelet concentrates, plasma was replaced with an additive solution.
Leukodepletion is performed in 100% of cases, and pathogen inactivation is performed in 98.2%. This ensures the absence of transfusion reactions when using platelets in the Republic of Bashkortostan. Conclusion. It would be preferable to replace the proposed regulated form of reporting on platelet procurement.

For citation: Khamitov R. G., Ayupova R. F., Shalygin L. D., Zhiburt E. B. Regulatory tool for improving the quality of donor platelet concentrates. Tromboz, gemostaz i reologiya. 2024;(4):53–58. (In Russ.).

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