Age-related features of the functional properties of blood cells in normal conditions and in chronic inflammation: 612.1:616-002.2

Abstract

Summary. Introduction. Cellular and tissue metabolism depends on the functioning of the microcirculation system, determined by blood rheological properties and hemostasis state. Studying these blood properties at different stages of human ontogenesis is a contemporary area of scientific inquiry. Similar studies in pathological, including inflammatory, processes are of particular interest. Аim: to study agerelated features of human blood cell functions under normal conditions and in inflammatory bowel diseases (IBD). Materials and Methods. We conducted a descriptive study that included two groups of subjects of both sexes: 132 almost healthy individuals at the age of 5–6 years (n = 30), 7–11 years (n = 34), 12–17 years (n = 32), 18–25 years (adults, n = 36) and 149 patients with IBD (Crohn’s disease, nonspecific ulcerative colitis) of a similar age — 5–6 years (n = 17), 7–11 years (n = 34), 12–17 years (n = 67), 18–25 years (adults, n = 31). The study examined blood rheological properties — erythrocyte deformability, aggregation, and disaggregation, as well as platelet functional properties, specifically their activation and aggregation. Results. The ontogenesis of healthy individuals is characterized by a tendency towards increasing erythrocyte aggregation. Similarly, platelet activation and aggregation are altered. Multidirectional changes in erythrocyte disaggregation and a tendency towards diminished deformability were also observed. An increase in chronological age in patients with IBD is accompanied by an increase in erythrocyte deformability, a decrease in erythrocyte aggregation and functional properties of platelets. Moreover compared with the indicators of healthy individuals, pronounced disturbances in hemorheology and platelet hemostasis were noted. Conclusion.During ontogenesis, there are alterations in the blood rheological properties, including increased erythrocyte aggregation, changes in their disaggregation, and decreased deformability, as well as modifications in platelet functional properties, including increased activation and aggregation. Chronic inflammation is characterized by transformation of hemorheology and hemostasis, with the patients’ process of growth and development being accompanied by various changes in the functional properties of blood cells.

For citation: Popovicheva A. N., Martusevich A. K. Age-related features of the functional properties of blood cells in normal conditions and in chronic inflammation. Tromboz, gemostaz i reologiya. 2024;(4):59–67. (In Russ.).

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