The Modified Fragility Index in patientswith myocardial infarction aged 90 years and older

Abstract

Summary. Introduction. The growing proportion of the aging population necessitates development and implementation of tools for assessing
frailty in patients undergoing elective surgical intervention. However, no unified approach to diagnosing frailty syndrome in elderly patients
with myocardial infarction (MI) undergoing percutaneous coronary intervention (PCI) has been proposed. Aim: to evaluate the potential of
the Modified Fragility Index (MFI) in patients with MI aged 90 years and older. Materials and Methods. A retrospective study was conducted.
From January 2013 to December 2020, 183 patients with MI were consecutively admitted to Polyakov Samara Regional Clinical Cardiology
Dispensary. The average patients’ age was 91.7±1.9 years, with 132 (72.1%) of them being women. MFI was calculated for all patients at
admission to diagnose frailty syndrome. Results. The clinical and anamnestic features were assessed depending on the course of MI, as well
as the frequency of hospital complications. Starting from 0.18 MFI points, the incidence of class III–IV acute heart failure according to Killip
scale was 27.6%. The MFI value was associated with higher rates of hospital mortality. MFI scores increased with increasing frequency of
deaths during hospitalization in patients with MI aged 90 years and older. Thus, MFI scores from 0 to 0.09 were associated with zero deaths,
with 0.18–0.27 the mortality rate was 31.6% (n=31), with 0.36–0.45 — 33.3% (n=19), and 63.6% (n=7) with a score over 0.54 (p=0.004).
Conclusion. There is no hospital mortality in patients with MI and minimal manifestation of frailty (0–0.09 MFI points), while in patients with
scores over 0.18 the hospital mortality rate exceeds 30%.

For citation: Duplyakova P.D., PavlovaT.V., DuplyakovD.V. The Modified Fragility Index in patients with myocardial infarction aged 90 years and older.
Tromboz, gemostaz i reologiya. 2025;(3):64–70. (In Russ.).

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