Crohn’s disease-associated coagulopathy

Abstract

Summary. Introduction. Autoimmune coagulopathies are acquired bleeding disorders caused by the development of autoantibodies
against coagulation factors. Crohn’s disease is a disorder triggered by dysregulation of immune tolerance, with antibodies to blood coagulation factors being detected. Aim: to demonstrate a clinical observation of a rare combination of Crohn’s disease and combined coagulation
factor deficiency. Clinical case. Patient X., 61 years old, was admitted to a multidisciplinary hospital with the diagnosis of “Crohn’s disease.
Hereditary factor VII deficiency”. Upon admission, the patient complained of frequent loose stools up to 10 times a day mixed with blood
and mucus, abdominal pain without clear localization during the urge to defecate, general weakness, and body temperature increase to
38 °C. No manifestations of hemorrhagic diathesis (except for blood in stool) were observed. Family and medical history showed no data for
congenital hemostasis disorders. Determining the level of individual clotting factors (F) revealed decreased levels of FVII (4.1%), FXII (18.2%),
FX (42.3%). Management of moderate attacks of Crohn’s disease included systemic glucocorticosteroids, cytostatics, and antibiotics. When
the level of coagulation factors was re-assessed, their increase was noted: FVII — 107.6%, FX — 85.9%, FXII — 30.6%. Increased coagulation factor levels following glucocorticosteroid therapy confirmed the autoimmune genesis of the coagulation disorder. Conclusion. The
detection of a clotting factor deficiency is a reason for diagnosing diseases with underlying disruption of immune tolerance and detection
of antibodies against blood clotting factors.

For citation: Beliaeva E.L., Koloskov A.V., PhilippovaO.I., Viutrikh K.A., Tokareva I.P., MarchenkoV.N. Crohn’s disease-associated coagulopathy. Tromboz,
gemostaz i reologiya. 2025;(3):77–81. (In Russ.).

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