Diversity of fibrin stabilizing blood coagulation factor substrates

Abstract

Summary. The primary function of the fibrin stabilizing factor (factor XIII, FXIII, Laki-Lorand factor) is its catalytic involvement in the fibrin structure cross-links, which makes fibrin stable and more resistant to fibrinolysis. However, a growing body of studies shows that the effect of this factor is not limited to the fibrin clot stabilization. Fibrin-stabilizing factor plays an important role in inflammation, tissue regeneration, and intercellular interaction, which is determined by the diversity of its substrates. The presented literature review examines various mechanisms of Laki-Lorand factor activation, its sources, as well as some substrates other than fibrin, which thoroughly describe its functional diversity.

For citation: Galak I.R., Tsybikov N.N., Mamaev A.N., Momot A.P. Diversity of fibrin stabilizing blood coagulation factor substrates. Tromboz, gemostaz i reologiya. 2026;(1):21–28. (In Russ.).

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