TEG 5000 versus Haema 4T for bleeding causes diagnosis in cardiac surgery

Abstract

Summary. Introduction. Viscoelastic tests for assessing blood coagulation system are deservedly considered priority methods for identifying bleeding causes in cardiac surgery and selecting targeted treatment methods. The emergence of new similar methods requires their validation and adaptation. Aim: to analyze the agreement between thromboelastography (TЕG) results obtained by TEG 5000 (Haemonetic, USA) and Haema 4T (Medcaptain Medical Technology Co., PRC) analyzers in blood samples from patients undergoing cardiopulmonary bypass (СРВ). Materials and Methods. In a prospective observational study, whole venous blood samples from patients undergoing СРВ were analyzed by TEG 5000 and Haema 4T analyzers. Two test variants were used: kaolin-activated coagulation assay (for blood samples after heparin inactivation with protamine sulfate, n = 70) and kaolin-activated coagulation assay in the presence of heparinase (for blood samples before heparin inactivation, n = 61). Results. Comparison of TЕG values received by TEG 5000 and Haema 4T analyzers demonstrated strong correlation and a high degree of agreement within the reference ranges for both test options. Outside the reference intervals, the degree of agreement decreased, which previously applied to the kaolin test, as well as the reaction time value in the kaolin + heparinase test. This requires adjustment of the threshold values for initiating targeted therapy in the kaolin test: R > 8 minutes, α angle < 56°, and in the kaolin + heparinase test: R > 7 minutes. Conclusion. TEG 5000 and Haema 4T analyzers demonstrate a high degree of agreement within the reference range. Haema 4T can be a fully-fledged option in the treatment process, provided that adjustments are made to bleeding treatment protocols based on TEG 5000 parameters, taking into account differences in values between the two methods that occur outside the reference intervals.

For citation: Kupryashov A.A., Khicheva G.A., Tokmakova K.A., Margaryan M.Z. TEG 5000 versus Haema 4T for bleeding causes diagnosis in cardiac surgery. Tromboz, gemostaz i reologiya. 2026;(2):37–45. (In Russ.).

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